Formulation and Optimization of Gastro retentive Glimepiride Floating Matrix Tablets

Pharmaceutical Science-Pharmacy for Better Health

Abstract

The main objective of this research investigational studies is to formulate floating matrix tablets of glimipride by applying simplex  centroid  design  for  optimization  technique  and  by  direct  compression  method.  The  simplex  Centroid configuration was drilled as an enhancement strategy by adjusting the amount of three components all the while and holding back their total concentration constant. Ingredients HPMC K15m, Kappa-carrageenan and sodium bicarbonate as X1,X2,X3 independent Variables while response variables Y1 floating lag time Y1, Percentage drug released after 1 hour Y2% and t90 time  required  for  90%  were  considered  as  response  variable  factors  for  formulation  and  optimization  of  total  14 formulations simplex centroid design was applied. The measures of HPMC K15M (X1), kappa-Carrageenan (X2) and sodium bicarbonate (X3) were utilized as the autonomous factors while coasting slack time (Y1), Percentage drug discharged after 1 hour(Y2)  and  time  required  for  90%  (t90)  were  taken  as  the  reaction  factors.  According  to  the  simplex  centroid configuration complete 14 formulations were formulated. Matrices were evaluated for physical parameters, in-vitro buoyancy, swelling ability and adhesion retention period.  It was inferred that the blend of kappa carrageenan and HPMC K 15 M builds the adaptability in the release pattern of the drug. This examination sets up the utilization of simplex centroid structure in the advancement of coasting network tablets with least experimentation.