Investigation of Adsorptive Properties of Surfactant Modified Sepiolite for Removal of Ciprofloxacin

Pharmaceutical Science-Pharmaceutical analysis for Novel drug formulation

Abstract

Pharmaceutical residues, which are considered as emerging contaminants, have been frequently detected in various water including treated water, surface water, and underground water. Furthermore, it may pose a serious risk to the living organisms by enhancing bacterial drug resistance. However, the removal of CIP from aqueous solution is difficult by present water  treatment  methods.  The  previous  study  indicated  that  the  removal  of  CIP  by  conventional  wastewater  treatment technologies  is  generally  incomplete.  The  aim  of  this  study  was  to  evaluate  the  efficiency  of  surfactant  (cetyltri-methyl- ammonium bromide)-modified Sepiolite (SMS) for Ciprofloxacin antibiotics (CIP) adsorption in a batch mode technique. The effects of different system variables, adsorbent dosage, initial CIP concentration, temperature contact time were investigated and optimal experimental conditions were ascertained.   The results showed that as the amount of the adsorbent is increased, the percentage of CIP removal increase accordingly. Optimum temperature value for CIP adsorption was 50    . Maximum CIP was sequestered within 60 min from the start of every experiment. The results also showed that the best test conditions were obtained at i) initial concentration of  CIP 10 mg/L and adsorbent dosage 2 g/L as working solution have been selected as the optimum conditions by the batch process; ii) the removal percentage and the maximum adsorption capacity were found to be 99.1% and 63.84 mg/g iii) Four well-known kinetic models, the pseudo-first- and pseudo-second-order, Elovich and Intra-particle diffusion were used to correlate the adsorption kinetic data, with the pseudo-second-order  model giving better results; iv) Negative value of ∆Go   and positive value of ∆Hº indicates the feasibility of the process and indicates the spontaneous and endothermic nature of the adsorption; v) SMS adsorbent can be an attractive option for CIP antibiotic removal from diluted industrial effluents since test reaction made on simulated antibiotic wastewater showed better removal percentage of CIP.