Effect of Opuntia elatior on Alteration in Glutamic Oxaloacetic Transaminase activity induced by Gamma Radiation in Swiss Albino Mice

Pharmaceutical Science-Zoology

Abstract

When mice are exposed to gamma radiation, all the body systems are affected adversely. Liver enzymes which are responsible for removal of toxicity created by irradiation  increases in the body. Several herbs are known to reduce this toxicity. Opuntia elatior (OE) ,a cactus, was tested in this study for its activity to remove toxins induced by whole body exposure to Co60 gamma rays (6Gy).A moderate dose of OE (10 mg/kg body weight) was given orally to mice, before whole body irradiation and GOT activity was studied in their kidney at 1,3,5,10,15 and 30 post treatment days . Whole body gamma ray exposure increases GOT  activity  in  the  kidneys  also.  In  OE    pretreated animals  this increase  was significantly  lesser and  early recovery was observed. Two types of extracts were used in this study (ethanolic and acetonic). Both were able to reduce gamma radiation induced  increase  significantly  and almost  equally.  As OE  cladode  extracts  are quite  cheap  and produce  no side  effects(OE cladodes  are used as food), it may be used to prevent unwanted toxic effects of gamma radiation exposure.