SYNTHESIS, CHARACTERIZATION AND ANTI MICROBIAL ACTIVITY OF NOVEL CHALCONES AND ITS DI HYDRO PYRIMIDINENONES

Pharmaceutical Science-Pharma Chemistry

Authors

  • CH.M.M.PRASADA RAO Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • D.DHACHINAMOORTHI Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • M.MOUNIKA Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • M.PAVANI Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • SK. SHIREENNAAZ Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • CH. SRAVANI REDDY Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.
  • M. SRI ANNAPURNA Dept. Of Pharm. Chemistry, QIS College of Pharmacy, Vengamukka Palem, Ongole-523272.

Keywords:

Chalcones, Pyrimidone, Antimicrobial activity, Clasein-Schmidt condensation

Abstract

Novel chalcones were synthesized by condensing 1-(2-chlorophenyl) ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according  to  Clasein-Schmidt  condensation  reaction.  The  synthesized  chalcones  compounds were reacted with urea and ethanol upon cyclisation gives pyrimidone derivatives .All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.

 

Published

2022-06-17

How to Cite

CH.M.M.PRASADA RAO, D.DHACHINAMOORTHI, M.MOUNIKA, M.PAVANI, SK. SHIREENNAAZ, CH. SRAVANI REDDY, & M. SRI ANNAPURNA. (2022). SYNTHESIS, CHARACTERIZATION AND ANTI MICROBIAL ACTIVITY OF NOVEL CHALCONES AND ITS DI HYDRO PYRIMIDINENONES: Pharmaceutical Science-Pharma Chemistry. International Journal of Life Science and Pharma Research, 5(3), 13–16. Retrieved from https://ijlpr.com/index.php/journal/article/view/438

Issue

Volume 5 Issue 3, July - September 2015

Section

Research Articles
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