A SIMPLE HPLC METHOD FOR IN-VITRO DISSOLUTION STUDY OF SERTRALINE HYDROCHLORIDE IN TABLETS

Pharmaceutical Science-Chemistry

Authors

  • SUSHIL P. NARKHEDE Department of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, India
  • SANTOSH KUMAR SINGH Department of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, India
  • G. VIDYASAGAR Department of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, India

Keywords:

Sertraline Hydrochloride, Dissolution method, HPLC, Validation

Abstract

The main aim of present work was to develop and validate a dissolution test for Sertraline Hydrochloride in tablets using HPLC method. The dissolution established conditions were: 900 ml of 0.05M Acetate buffer pH 4.5 as dissolution medium, using a paddle apparatus at a stirring rate of 75 rpm. The chromatographic condition employed a C-18 column (Eurospehere, 250 x 4.6mm, 5µm), isocratic elution with Acetonitrile:Methanol:Phosphate buffer pH 3 (20:50:30 V/V/V) and UV detection at 274 nm. The method was validated to meet requirements for a global regulatory filing. The dissolution test developed was adequate for its purpose and could be employed for routine quality control of Sertraline Hydrochloride tablets.

Published

2022-06-17

How to Cite

SUSHIL P. NARKHEDE, SANTOSH KUMAR SINGH, & G. VIDYASAGAR. (2022). A SIMPLE HPLC METHOD FOR IN-VITRO DISSOLUTION STUDY OF SERTRALINE HYDROCHLORIDE IN TABLETS: Pharmaceutical Science-Chemistry. International Journal of Life Science and Pharma Research, 6(4), 22–28. Retrieved from https://ijlpr.com/index.php/journal/article/view/386

Issue

Volume 6 Issue 4, October - December 2016

Section

Research Articles
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.