SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 3-ARYL-5-IMIDAZOLYL-2-PYRAZOLINES

Life Sciences-Chemistry

Authors

  • MOHAMMAD ALI EBRAHIMZADEH Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
  • FERESHTEH POURMORAD M. A. Ebrahimzadeh, Department of Medicinal Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences,

Keywords:

Antimicrobial activity, Chalcones, Imidazole, Pyrazoline.

Abstract

Pyrazolines are well known and important nitrogen containing five membered heterocyclic compounds. Considerable interest has been focused on the pyrazoline structure, which has been known to possess a broad spectrum of biological activities. Reaction of α,β-unsaturated aldehyde and/or ketones with hydrazines is one of the most popular method for the preparation of 2- pyrazolines.  In  this  study  a  new  series  of  3-aryl-5-imidazolyl-2-pyrazolines  have  been synthesized  and evaluated  for their antibacterial  and antifungal  activities.  Desired  chalcones were prepared by condensing appropriate acetophenones with substituted imidazole-5- carboxaldehyde. Reaction of chalcones with phenyl hydrazine, hydrazine hydrate or thiosemicarbazide gave desirable pyrazolines. Compounds with thiosemicarbazide and para hydroxyl substitution showed potent antibacterial activity. This is consistent with the observation made earlier by other researchers. The compounds did not show any antifungal activity.

Published

2022-06-17

How to Cite

MOHAMMAD ALI EBRAHIMZADEH, & FERESHTEH POURMORAD. (2022). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 3-ARYL-5-IMIDAZOLYL-2-PYRAZOLINES: Life Sciences-Chemistry. International Journal of Life Science and Pharma Research, 6(3), 38–43. Retrieved from https://ijlpr.com/index.php/journal/article/view/381

Issue

Volume 6 Issue 3, July-September 2016

Section

Research Articles
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