ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF PETROLEUM- ETHER EXTRACT OF EUPATORIUM TRIPLINERVE VAHL

Pharmaceutical Science-Pharmacology

Abstract

The petroleum-ether extract of E.triplinerve Vahl was subjected to preliminary phytochemical screening. Acute toxicity studies were carried out in Swiss albino mice. Analgesic activity of petroleum-ether extract was evaluated by well established models like acetic acid induced writhing, formalin test and tail immersion method in mice. The acute anti-inflammatory effect was studied by carrageenan induced hind paw edema method in rats. Phytochemical evaluation revealed the presence of sterols, alkaloids, tannins, phenols and glycosides. Acute toxicity studies showed that the extract was non-toxic upto a maximum dose of 2000 mg/kg body weight. Petroleum-ether extract exhibited significant inhibition of acetic acid induced writhing, reduced the paw-licking response time significantly in formalin test and increased the withdrawal latency time in tail immersion test. Carrageenan induced hind paw edema was significantly reduced in rats.The present study indicates that the petroleum-ether extract of Eupatorium triplinerve Vahl has potential antinociceptive and anti-inflammatory activity.