FORMULATION, OPTIMIZATION, AND EVALUATION OF ASENAPINE MICROSPHERES USING SOLVENT EVAPORATION
DOI:
https://doi.org/10.22376/ijlpr.v16i1.2034Keywords:
Asenapine, Microspheres, Invitro dissolution studies, swelling indexAbstract
The objective of the present study was formulation and evaluation of Asenapine microspheres by using solvent evaporation technique. Asenapine is loaded with ethyl cellulose & HPMC 15 microspheres and it was prepared by solvent evaporation method. Asenapine used in the treatment of psychotric patients. The results of FTIR indicated the stable character of Asenapine microspheres loaded with ethyl cellulose, HPMC K15M there is no incompatability between drug & polymers. The Morphological characters of Asenapine microspheres is carried out by SEM. From the results it seem that formulation AM 8 was found to be the excellent Morphological properties, % yield of microsphere of best formulation was found to be AM 8 (86.92%), Entrapment efficiency of best formulation was found to be (75.6 %) , Drug loading efficiency of best formulation was found to be (88.1 %), Swelling index best formulation was found to be (1.3 sec), Particle size of best formulation was found to be (102 µm), Drug content determination of best formulation was found to be (97.4) and in vitro drug release was fitted with various Release kinetic studies of a sustained manner with constant fashion over extended period of time for 45 Mints. It was observed that concentration of Ethyl cellulose affected all the evaluation parameter significantly. Hence the prepared microspheres of Asenapine may prove to be potential candidate for safe and effective sustained drug delivery.
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