New Therapeutic Compounds and Recent Advancements in Metastasis Cancer Treatment: A Review
Life Sciences-Biotechnology
DOI:
https://doi.org/10.22376/ijlpr.2023.13.6.L132-L143Keywords:
Cancer, Metastasis, Phytochemicals, Drugs, Gene Therapy, Stem Cell Therapy.Abstract
Cancer is one of the major diseases with extremely high mortality, accounting for nearly 10 million deaths in 2020.Even though immense research has been done in this domain, a need to develop effective therapeutic strategies still exists.Chemotherapeutic drugs form a crucial part of anti-cancer therapy. The current study summarizes the traditional and recentlydeveloped novel therapeutic drugs for advanced and effective cancer treatment with this perspective. Advanced cancertreatments involve photodynamic therapy, targeted therapy, Stem cell therapy, Gene therapy, and hormonal therapy to mitigateCancer. Photodynamic therapy is a special type of cancer treatment in which a person is injected with a unique light-sensitivedrug that stays in the cancer cells for a long time to maintain normal health. Stem cell therapy is advanced for cancer therapyand more effective than other therapies. Stem cells are used to regenerate damaged tissues. About 2000 gene therapy clinicalinvestigations are ongoing in cancer research and therapy. Mostly involved with chemo sensing genes and expression of wildtype tumor suppressor genes. The reported advanced treatments may have more effective and targeted treatments andprevention strategies than conventional treatments. We believe this review will provide the readers with the current state-ofthe-art knowledge of anti-cancer drugs and open the horizon for further development of novel anti-cancer therapeutics.
References
IqbalN, IqbalN. Human epidermal growth factor Receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int. 2014:1-9.
Elzeblawy Hassan H, Mohammed RA, Salam Ramadan SAE, kamal masaud H. Call for alleviatingsexualissues among cervical cancer survivors’ Women in northernupperEgypt. J ObstetGynecol ReprodSci.2021;5(3):1-10. doi: 10.31579/2578-8965/066.
Ramadan S, Hassan H, Masaud H, Mohammed R. Women’s body image distress associated with cervical cancer. J ObstetGynecol ReprodSci.2021;5(3):1-6. doi: 10.31579/2578-8965/062.
Kamal H, Ali R, Abd El Salam S, Hassan H. Self-knowledge among Women with cervicalcancer. J Cancer Res Treat.2021;9(1):12-21. doi: 10.12691/jcrt-9-1-2.
Elzeblawy H, Kamal H, Abd El Salam S, Ali R. Survivors from cervicalcancer: impact of an educationalprogram on self-knowledge and body-image. Public Health Open Access.2021;5(1):1-9. doi: 10.23880/phoa-16000175.
Hassan H, Ali R, Abd El Salam S, Kamal H. Impact of an educationalprogram on sexualdysfunctionassociated with cervicalcancer. J Cancer Res Treat.2021;9(2):22-31. doi:10.12691/jcrt-9-2-1.
Timothy MP, Candice BL, Kristy LR. Past, present, and future of rituximab: theWorld’sfirstoncologymonoclonal antibodytherapy. Front Oncol.2018;8(163):1-23.
Ali R, Kamal H, Hassan H, Abd El Salam S. Impact of an educational program on sexualdistressassociated with cervical cancer. J Appl Health Sci Med.2021;1(1):30-42.
Masaud H, Elzeblawy Hassan H, Mohammed R, Ramadan S. Women’s sexualdistressassociated with cervicalcancer. Sumerianz J Med Healthc.2021;4(41):28-34. doi: 10.47752/sjmh.41.28.34.
Hassan H, Ramadan S, Ali R, Kamal H. Sexual issues among cervicalcancersurvivors’Women in northernupperEgypt. J Adv TrendsBasic ApplSci.2021;1(1):1-11.
Abd El Salam AR, Hassan H, Kamal H. Outcome of an educationalprogram on bodyimagedistressassociated with cervicalcancer. J Adv TrendsBasic ApplSci.2021;1(1):12-20.
Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah Ret al.CHOP Chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med.2002;346(4):235-42. doi: 10.1056/NEJMoa011795, PMID 11807147.
HassanH, BayoumiM, AtwaA. Emotional distressassociated with gynecologic and breastcancer in Beni-Suef city. IntJ Sci Res.2016;5(2):1118-29.
Nady F, Said M, Youness E, Hassan H. Impact of tailorededucationalprogram of quality-of-lifeimprovement on womenundergoingbreastcancertreatment at El Minia Region, Egypt. American Research Journal of Gynaecology. 2017;1(1):1-17. doi:10.21694/2577-5928.17001.
Mohammed F, Shahin M, Youness E, Hassan H. Survivorship in womenundergoinggynecological and breastcancertreatment in upperEgypt: theimpact of quality-of-lifeimprovementeducationalprogram. AmResJ Gynaecol. 2018;2(1):1-28. doi:10.21694/2577-5928.18001.
Said S, Hassan H, Sarhan A. Effect of an educationalintervention on women’s knowledge and attituderegardingcervicalcancer. AmJ NursRes. 2018;6(2):59-66. doi: 10.12691/ajnr-6-2-4.
Dagher R, Cohen M, Williams G, Rothmann M, Gobburu J, Robbie Get al.Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin Cancer Res.2002;8(10):3034-8. PMID 12374669.
Damiani E, Wallace HM. Polyamines and cancer. Mol Biol.2018; 1694:469-88.
Atwa A, Hassan H, Ahmed S. The impact of a hospital-based awareness program on the knowledge of patients about breast cancer and cancer cervix. IntJ Stud Nurs. 2019;4(1):20-9. doi:10.20849/ijsn. v4i1.537.
Nady F, El-Sherbiny M, Youness E, Hassan H. Effectiveness of quality-of-lifeplannedteachingprogram on women undergoing gynecologic cancer treatment. AmResJ Oncol. 2018;1(1):1-17.
MohamedAA, HassanHE, GamelWMA, ArafaAE. Awareness about breast and cervical cancers among nursing students in Beni-Suef University. J NursEduc Pract.2019;9(5):44-51. doi: 10.5430/jnep.v9n5p44.
Zagloul M, Naser E, Hassan H. Cervical cancerknowledge, attitude, and practices: educationalprogrammanagement for femaleworkers at Port Saiduniversity. IntJ Stud Nurs.2020;5(3):1-16. doi:10.20849/ijsn. v5i3.776.
Abd El Salam S, Hassan H, Kamal K, Ali R. Sexual dysfunction of women’s associated with cervicalcancer. J Appl Health Sci Med.2021;1(2):12-27.
Elzeblawy Hassan H, Ali R, El Salam SA, Kamal H. Women with Cervical Cancer: impact of an Educational Program their knowledge. J ObstetGynecol ReprodSci.2021;5(2):1-8. doi: 10.31579/2578-8965/063.
Masaud H, Abd Rabo R, Ramadan S, Hassan H. Impact of protocol of nursingintervention on sexualdysfunction among Women with cervicalcancer.2021;2(2):203-24.
Brouwer C, De Abreu RA, Keizer-Garritsen JJ, Lambooy LH, Ament K, ter Riet PGet al.Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects. Eur J Cancer.2005;41(4):613-23. doi: 10.1016/j.ejca.2004.10.027, PMID 15737567.
QalawaSh, EldeebA, HassanH. Young Adult Women’s intention regarding breast and cervical cancer screening in Beni-Suef [scientificresearchjournal].2015;3(3):11-24.
Nady F, Said M, Youness E, Hassan H. Effect of nursinginterventionprogram on quality-of-lifeimprovement for womenundergoinggynecological and breastcancertreatment. Assuit SciNursJ.2018;6(15):62-77.
Hassan H, Masaud H, Mohammed R, Ramadan S. Self-knowledge and bodyimage among cervicalcancersurvivors’Women in northernupperEgypt. J Appl Health Sci Med.2021;1(1):1-12.
HassanH, MasaudH, MohammedR, RamadanS. Self-knowledge, and bodyimage among cervicalcancersurvivors’Women in northernupperEgypt. J Appl Health Sci Med.2021;1(1):1-12.
Elzeblawy Hassan H, Mohammed R, Ramadan S, Masaud H. Impact of an educationalprogram on sexualissues among cervicalcancersurvivors’Women in northernupperEgypt. J ObstetGynecol ReprodSci.2021;5(1):1-15. doi: 10.31579/2578-8965/095.
Nur SNH, Azizah U2, Nor FR, Mohd FA, Michael F, Sze LL, Nur NMA. Combination Therapy of Navitoclax with Chemotherapeutic Agents in Solid Tumors and Blood Cancer: A Review of Current Evidence. Pharmaceutics 2021;13(9):1-12.
DelochL, Derer A, Hartmann J, Frey B, Fietkau R, Gaipl US. Modern radiotherapyconcepts and the impact of radiation on immuneactivation. Front Oncol.2016;6:141. doi: 10.3389/fonc.2016.00141, PMID 27379203.
Gao Y, Shang Q, Li W, Guo W, Stojadinovic A, Mannion Cet al.Antibiotics for cancer treatment: A double-edged sword. J Cancer.2020;11(17):5135-49. doi: 10.7150/jca.47470, PMID 32742461.
Olano C, Méndez C, Salas JA. Antitumor compounds from marineActinomycetes. Mar Drugs.2009;7(2):210-48. doi: 10.3390/md7020210, PMID 19597582.
Agarwal N, Yeole BB, Ram U. Lifetime risk and trends in lung cancer incidence in greater Mumbai. Asian Pac JCancer Prev.2009;10(1):75-82. PMID 19469629.
Diaby V, Tawk R, Sanogo V, Xiao H, MonteroAJ. A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat.2015;151(1):27-40. doi: 10.1007/s10549-015-3383-6, PMID 25893588.
Nath A, Sathishkumar K, Das P, Sudarshan KL, Mathur P. A clinicoepidemiological profile of lung cancers in India - Results from the National Cancer Registry Programme. Indian J Med Res.2022;155(2):264-72. doi: 10.4103/ijmr.ijmr_1364_21, PMID 35946203.
Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santhappan Set al.Cancer statistics: report from nationalcancerregistryprogramme, India. JCO Glob Oncol.2020;6:1063-75.
Guideline on development, production, characterisation, and specification for monoclonal antibodies. Eur Med, (Agency)/CHMP/205/95. 2017.
FaguetGB. A brief history of cancer: age-old milestones underlying our current knowledge database. Int J Cancer.2015;136(9):2022-36. doi: 10.1002/ijc.29134.
Pallavi SS, Bhat MP, Nayaka S. Amycolatopsis sp. strain MN235945 mediatedbiosynthesis of silvernanoparticles: characterization, antimicrobial and anticanceractivity against HeLa and MCF-7 celllines. Indian J Pharm Sci.2022;84(5):1178-88.
Izraeli S. The first achievement of complete remission in childhood leukemia by treatment with the folic acid antagonist aminopterin. Haematologica.2022;107(4):782-. doi: 10.3324/haematol.2022.280670, PMID 35359155.
Fasolo A, Sessa C. Targeting mTOR pathways in human malignancies. Curr Pharm Des.2012;18(19):2766-77. doi: 10.2174/138161212800626210, PMID 22475451.
Fauvel B, Yasri A. Antibodies directed against receptor tyrosine kinases. mAbs.2014;6(4):838-51. doi: 10.4161/mabs.29089.
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo Met al.Cancer incidence and mortality worldwide: sources, methods, and major patterns in GLOBOCAN2012. Int J Cancer.2015;136(5):E359-86. doi: 10.1002/ijc.29210, PMID 25220842.
Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun.2012;425(3):540-7.
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov.2004;3(5):391-400. doi: 10.1038/nrd1381, PMID 15136787.
Fessas P, Lee H, Ikemizu S, Janowitz T. A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab. Semin Oncol.2017;44(2):136-40. doi: 10.1053/j.seminoncol.2017.06.002, PMID 28923212.
Fiedler W, Serve H, Döhner H, Schwittay M, Ottmann OG, Farrell AM. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood.2003;102:2763-7.
Hillmen P. Using the biology of chronic lymphocytic leukemia to choose treatment. American Society of HaematologyEdu Program;2011.
Flaherty KT. Chemotherapy and targeted therapy combinations in advanced melanoma. Clin Cancer Res.2006;12(7 Pt 2):2366s-70s. doi: 10.1158/1078-0432.CCR-05-2505, PMID 16609060.
Cho RC, Cole PD, Sohn KJ, Gaisano G, Croxford R, Kamen BAet al.Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells. Mol Cancer Ther.2007;6(11):2909-20. doi: 10.1158/1535-7163.MCT-07-0449, PMID 18025275.
Kumari R, Saini AK, Kumar A, Saini RV. Apoptosis induction in lung and prostate cancer cells through silver nanoparticles synthesized from Pinus roxburghii bioactive fraction. J Biol Inorg Chem.2020;25(1):23-37. doi: 10.1007/s00775-019-01729-3, PMID 31641851.
Galmarini CM, Mackey JR, Dumontet C. Nucleoside analogues and nucleobases in cancer treatment. Lancet Oncol.2002;3(7):415-24. doi: 10.1016/s1470-2045(02)00788-x, PMID 12142171.
Johnston PG, Kaye SB. Capecitabine: a novel agent for treatment of solid tumours. AntiCancer Drugs.2001;12:639-46.
Qiu MT, Ding XX, Hu JW, Tian HY, Yin R, Xu L. Fixed-dose rate infusion and standard rate infusion of gemcitabine in patients with advanced non-small-cell lung cancer: a meta-analysis of six trials. Cancer Chemother Pharmacol.2012;70(6):861-73. doi: 10.1007/s00280-012-1974-z, PMID 23053260.
Kim KI, Huh IS, Kim IW, Park T, Ahn KS, Yoon SS, et al. Combined interaction of multi-locus genetic polymorphisms in cytarabinearabinoside metabolic pathway on clinical outcomes in adult acute myeloid leukaemia (AML) patients. Eur J Cancer.2013;49(2):403-10. doi: 10.1016/j.ejca.2012.07.022, PMID 22964418.
Lucas DM, Still PC, PérezLB, Grever MR, Kinghorn AD. Potential of plant-derived natural products in the treatment of leukemia and lymphoma. Curr Drug Targets.2010;11(7):812-22. doi: 10.2174/138945010791320809, PMID 20370646.
Mano M. Vinorelbine in the management of breast cancer: new perspectives, revived role in the era of targeted therapy. Cancer Treat Rev.2006;32(2):106-18. doi: 10.1016/j.ctrv.2005.12.008, PMID 16473470.
Luca F, Salvatore S, Massimo L. Evolution of cancerpharmacologicaltreatments at the turn of the thirdmillennium. Front Pharmacol.2018;9(1300):1-26.
Gampenrieder SP, Bartsch R, Matzneller P, Pluschnig U, Dubsky P, Gnant MXet al.Capecitabine and vinorelbine as an all-oralchemotherapy in HER2-negativelocallyadvanced and metastaticbreastcancer. Breast Care (Basel).2010;5(3):158-62. doi: 10.1159/000314214, PMID 21048830.
Gordon MC, David JN. Plants as a source of anticancer agents. J Ethnopharmacol.2005;100(1-2):72-9.
Miele E, Spinelli GP, Miele E, Tomao F, Tomao S. Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer. Int J Nanomedicine.2009;4:99-105. doi: 10.2147/ijn.s3061, PMID 19516888.
Isah T. Anticancer alkaloids from trees: development into drugs. Pharmacogn Rev.2016;10(20):90-9. doi: 10.4103/0973-7847.194047, PMID 28082790.
Paolo AA, Grant AM, Brigitte D, Victoria A4, Gabrielle L, Anna MD6, Mario M, Lev D, Daniil S, Luc T, Luis M, Caroline D, Claus G, Yibing Y, Matthew W, Ilsung C, Jessie JH, Daniel OK, Isabelle R, Antoni R, James L. Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial. Lancet Oncol 2016;17(9):1248- 60.
Teng W, Chunhao C, Mehrad G, Maryam S, Xiaofeng R. Using nanotechnology for diagnosis and treatment of breastcancer: areview. Indian J Pharm Sci.2022;2:237-45.
Haanen JB, Robert C. Immune checkpointinhibitors. Tumor Res.2015;42:55-66.
Mahoney KM, Rennert PD, Freeman GJ. Combination cancer immunotherapy and new immunomodulatory targets. Nat Rev Drug Discov.2015;14(8):561-84. doi: 10.1038/nrd4591, PMID 26228759.
DeVita VT, DeVita-Raeburn E, Moxley JH. Intensive combinationchemotherapy and X-irradiation in Hodgkin’s disease. Cancer Res.2016;76(6):1303-4. doi: 10.1158/0008-5472.CAN-16-0470, PMID 26979790.
Shaikh AY, Shih JA. Chemotherapy-inducedcardiotoxicity. Curr Heart FailRep.2012;9(2):117-27. doi: 10.1007/s11897-012-0083-y, PMID 22382639.
Cassileth BR, Vickers AJ. High prevalence of complementary and alternativemedicineuseamongcancerpatients: implications for research and clinicalcare. J Clin Oncol.2005;23(12):2590-2. doi: 10.1200/JCO.2005.11.922, PMID 15728221.
Huifen Z, Fan G, Xiaojun Z, Miaomiao J, Haibo Y, Yarong Yet al.Anthracycline Chemotherapy in Treating Advanced Breast Cancer and its effect on estradiol and Tumor Size. Indian J Pharm Sci.2020;1:124-8.
Shanshan W, Qian M, Qing X, Man Z. Effect and mechanism of resveratrol on drug resistance in human bladder cancer cells. Mol Med Rep.2017;15(3):1179-87.
Takeishi S, Nakayama KI. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells. Br J Cancer.2014;111(6):1054-9. doi: 10.1038/bjc.2014.259, PMID 24853181.
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith Iet al.Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.N Engl J Med.2005;353(16):1659-72. doi: 10.1056/NEJMoa052306, PMID 16236737.
Strauss GM, Herndon J, Maddaus MA, Johnstone DW, Johnson EA, Watson DM. Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage ibidnon-small cell lung cancer (nsclc): report of cancer and leukemia group b (calgb) protocol. J Clin Oncol.2004;22:7019.
Lim S, Metzger E, Schüle R, Kirfel J, Buettner R. Epigenetic regulation of cancer growth by histone demethylases. Int J Cancer.2010;127(9):1991-8. doi: 10.1002/ijc.25538, PMID 20607829.
Pavlova NN, Thompson CB. The emerginghallmarks of cancermetabolism. Cell Metab.2016;23(1):27-47. doi: 10.1016/j.cmet.2015.12.006, PMID 26771115.
Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev.2008;18(1):54-61. doi: 10.1016/j.gde.2008.02.003, PMID 18387799.
Wu HC, Chang DK, Huang CT. Targeted therapy for cancer. JCancer Mol.2016;2:57-66.
Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett.2004;215(2):129-40. doi: 10.1016/j.canlet.2004.07.013, PMID 15488631.
Rebecca SL, Kimberly MPH, Miller D, Hannah MPH, Fuchs E, Ahmedin BSet al.A cancer Journal for Clinicians. Cancer statistics2021.
Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol.2005;205(2):275-92. doi: 10.1002/path.1706, PMID 15641020.
Nishida S, Tsubaki M. Exploration of moleculartargets in the development of newtherapeuticsaimed at overcomingmultidrug resistance. J of Phasociety of Japan.2017;137(2):145-9.
Lu BC, Li J, Yu WF, Zhang GZ, Wang HM, Ma HM. Elevated expression of Nrf2 mediates multidrug resistance in CD133+ head and neck squamous cell carcinoma stem cells. Oncol Lett. 2016;12(6):4333-8. doi: 10.3892/ol.2016.5269, PMID 28101198.
Debela DT, Muzazu SG, Heraro KD, Ndalama MT, Mesele BW, Haile DCet al.New approaches and procedures for cancer treatment: current perspectives. SAGE Open Med. 2021;9:20503121211034366. doi: 10.1177/20503121211034366, PMID 34408877.
Kifle ZD, Tadele M, Alemu E, Gedamu T, Ayele AG. A recent development of new therapeutic agents and novel drug targets for cancer treatment. SAGE Open Med. 2021;9:1-12.
DataSource: New Global Cancer Data, GLOBOCON;2020.Available from: http://gco.iarc.fr.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Jana Debarati, Koteswara Reddy G, Hari Sai Ram A, Hyacinthe Tuyubahe, Allam Ganesh, Vempati Gopi Krishna, Janaki Ramaiah Mekala
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
