Pharmaceutical Standardization of Muktashukti Bhasma and Muktashukti Pishti
DOI:
https://doi.org/10.22376/ijlpr.2023.13.3.SP1.L64-L70Keywords:
Shodhana, Marana, Muktashukti, Bhasma, PishtiAbstract
Shukti is an important component of Sudhavarga, the most recent class in the subject of Rasa Shastra. According to the availability, two forms of Shukti have been stated in Rasa Shastra texts: Jalashukti and Muktashukti. Muktashukti is considered for the study. This study has tried to develop the standard operating process for manufacturing Muktashukti bhasma and Muktashukti pishti. Three batches of MSB & MSP were prepared from the purified Muktashukti. While manufacturing three batches same raw material and manufacturing instruments were used. Before processing for Bhasma or Pishti, the purification process is advocated for Muktashukti. Kanji (Rice gruel) was used for purification as per textual reference. Purified Muktashukti was levigated with Rose water to obtain Pishti. However, for Bhasma preparation, the Muktashukti was triturated with Aloe vera juice, and then heating was done in an Electric muffle furnace. 7 liters of Kanji was taken for 500g of Muktashukti Shodhana by Swedana for 3hrs in Dolayantra, with an average weight rise of 96.24% and a weight loss of 3.76% during the Shodhana method. During MSB preparation, a 10% loss was observed & 90% of Bhasma was obtained. However, in MSP preparation, a 12.14% loss was observed & 87.86% was obtained. This study will give the direction related to the duration of levigation and temperature regulation while Muktashukti Bhasma preparation. For Pishti preparation, the wet grinder was used, which will provide exact rotation and duration to obtain the proper pishti from Muktashukti.
References
Pande AP, Deshpande SB, Gokarna RA, Wanjari AS. Rasayana Loha Kalpas explained in Rasa Ratna Samucchaya. J Indian Syst Med. 2015 Jan 1;3(1):30.
Indu S, Kumar PA, Rao SK, Jayaram H. Ayurvedic perspective of calcium supplementation-A review. Vitam Miner. 2019;4;8: 185. of:2376-1318.
Kamble S, Wanjari A, Rathi B, Rajput D. Pharmaceutico-Analytical Study of Muktashukti Pishti and Muktashukti bhasma and Comparative Evaluation of their Relative Oral Bioavailability. J Pharm Res Int. 2021;33(31B):1-9. doi: 10.9734/jpri/2021/v33i31B31680.
Swer et al. Pharmaceutical and analytical study of Tryushanadya Lauha & Modified Form as Tryushanadya Madura and their Comparative Evaluation for Antidiabetic activity in Wistar rats. J Pharm Res Int. 2021;33(60B):2947-57.
Bandari S, Bhadra Dev P, Murthy PH. A concept of Sodhana (Purification) wsr to parada (mercury). Int J Ayurvedic Med. 2011;2(3):119-27.
Khare CP. Ayurvedic pharmacopoeial plant drugs: expanded therapeutics. CRC Press; 2015 Nov 18.
Rajput DS, Gokarn R, Wanjari A, Rathi B. Aspects of pre-formulation in Bhasma Kalpa (Incinerated metallic drug or medicines). J Indian Syst Med. 2015 Apr 1;3(2):91.
Farooq S, Mehmood Z, Qais FA, Khan MS, Ahmad I. Nanoparticles in ayurvedic medicine: potential and prospects. InNew look to phytomedicine 2019 Jan 1 (pp. 581-96). Academic Press.
Bharti T, Sharma P, Sharma P. Concept of NANO particle formulation in AYURVEDA–bhasma: a critical review.
Singh RK, Kumar S, Aman AK, Karim SM, Kumar S, Kar M. Study on physical properties of Ayurvedic nanocrystalline Tamra Bhasma by employing modern scientific tools. J Ayurveda Integr Med. 2019 Apr 1;10(2):88-93. doi 10.1016/j.jaim.2017.06.012, PMID 29249635.
Soumya P, Kalyani SS, Chabnur SM. An Ayurvedic approach to Post Covid Symptoms. J Ayurveda Integr Med Sci. 2021 Sep 15;6(4):235-41.
Mitra S, Prajapati PK, Shukla VJ, Ravishankar B. Impact of BhavanaSamskara on physico-chemical parameters with special reference to GandhakaRasayana prepared by different media and methods. Ayu. 2010 Jul;31(3):382-6. doi: 10.4103/0974-8520.77155, PMID 22131744.
RavindraAngadi RT. Shloke No 12/66, ChaukhambaSurbharatiPrakashan, Pg. No-199.
Mallick A. Ayurvedic drugs from marine originates.
Saroch V, Kundailia N. A review on marine originated drug tradition in AYURVEDA.
Sinha S, Singh RK, Kumar N, Singh SP, Dwivedi PK, Kumari R. Preparation and Exploration of Physical Properties of calcium-based Indian Origin Ayurvedic Medicine-Shankh Bhasma (Marine Drug) as Nanomaterials for its Applications. J Nat Rem. 2021 Jul 6;21(3):225-34. doi: 10.18311/jnr/2021/26225.
Singh IP, Ahmad F, Chatterjee D, Bajpai R, Sengar N. Natural products: drug discovery and development. In: Drug discovery and development. Singapore: Springer; 2021. p. 11-65.
Belge VR, Pandey R, Itankar P. Critical Review of Bhavana Processes with special reference to its Utility in Ayurvedic Pharmaceutics. J Ayurveda Integr Med Sci. 2019 Jun 30;4(03):126-31.
Rathi B, Rathi R, Rajput DS. Pharmaceutical standardization of Avalgujadi Lepaguti. J Ind Sys. Med. 2016 Apr 1;4:72-6.
Ali HS, Suliman RS, Elhaj BM, Suliman R. A recent progress and manufacturing techniques in pharmaceutical powders and granulation. Int J Pharm Clin Res. 2019;11(1):1-2.
Batchelor AW, Jana S, Koh CP, Tan CS. The effect of metal type and multi-layering on friction surfacing. J Mater Process Technol. 1996 Feb 1;57(1-2):172-81. doi: 10.1016/0924-0136(95)02057-8.
Satpute M, Rathi B, Wanjari A, Khan M. Comparative pharmaceutical standardization and oral bioavailability study on Praval Pishti and Praval Bhasma. J Pharm Res Int. 2021;33:54-60. doi: 10.9734/jpri/2021/v33i31B31690.
Shankar G, Doddamani MS. Analytical assessment of Akika Pishti based on Ancient and Modern Parameters. J Ayurveda Integr Med Sci. 2017 Jun 30;2(03):92-100.
Sharma R, Bedarkar P, Timalsina D, Chaudhary A, Prajapati PK. Bhavana, an ayurvedic pharmaceutical method and a versatile drug delivery platform to prepare potentiated micro-nano-sized drugs: core concept and its current relevance. Bioinorg Chem Appl. 2022 Apr 29;2022:1685393. doi: 10.1155/2022/1685393, PMID 35529314.
Nisha KU. Basic Princi PLES of RASA SHASTRA-pharmaceutics of HERBO-mineral formulations.
Rajput D, Mesram P, Patgiri BJ. Critical review on pharmaceutical prospects of Naga Bhasma (incinerated lead). Int J Pharm Biol Archiv. 2014;5:46-53.
Pal D, Gurjar VK. Nanometals in Bhasma: ayurvedic medicine. In metal nanoparticles in pharma 2017 (pp. 389-415). Cham: Springer.
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