SIMULTANEOUS ESTIMATION OF LAMIVUDINE AND STAVUDINE IN TABLET DOSAGE FORM BY RP-HPLC

Pharmaceutical Science-Pharmacology

Abstract

Lamivudine is a potent ‛‛reverse transcriptase inhibitor ’’ belonging to the class of nucleoside analog reverse
transcriptase inhibitor (NARTI). Stavudine is an anti-HIV treatment drug in the class of drugs called nucleoside
reverse transcriptase inhibitors (NRTIs). Both are excellent anti-retroviral drugs, widely used clinically in the
treatment of infections which are related to immuno deficiency virus. The present combination of Lamivudine
and Stavudine was marketed as one tablet dosage form formulation with a dose of Lamivudine 150mg/tab and
Stavudine 40mg/tab. Although various methods have been developed for the estimation of Lamivudine and
Stavudine individually and in combination with other drugs, no official method has been published with the
combination of these drugs. The fixed dose combination of Lamivudine and Stavudine was subjected to
simultaneous estimation by Reverse phase HPLC method