Prevalence of Thyroid Diseases in Diabetics Patients at King Fahad General Hospital in Jeddah, Saudi Arabia

Pharmaceutical Science-Pharmacology and therapeutics

Authors

  • Raghad Saud Almatani Pharm D candidate, Faculty of Pharmacy, Um Al -Qura University, Makkah, KSA.
  • Asmaa Sulaiman Alsahaf Pharm D candidate, Faculty of Pharmacy, Um Al -Qura University, Makkah, KSA.
  • Maram Bakheet Alluhaybi Pharm D candidate, Faculty of Pharmacy, Um Al -Qura University, Makkah, KSA.
  • Renad Abdulaziz Refaai Pharm D candidate, Faculty of Pharmacy, Um Al -Qura University, Makkah, KSA.
  • Wajdan Ibrahim Alharbi Pharm D candidate, Faculty of Pharmacy, Um Al -Qura University, Makkah, KSA.
  • Yosra Alhindi Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia https://orcid.org/0000-0002-5725-3522

DOI:

https://doi.org/10.22376/ijlpr.2023.13.1.P129-135

Keywords:

Thyroid Diseases, Prevalence, Diabetes Mellitus Type I, and Diabetes Mellitus Type II.

Abstract

Progressive disease that is Diabetes is a chronic disorder that is characterized by elevated blood glucose levels. The global prevalence of this disorder has nearly doubled among adults. Diabetes Mellitus (DM) and thyroid diseases are the most common endocrine disorders in clinical practice. Several studies have shown that diabetes mellitus is associated with an increased incidence of thyroid disorders. The main aim of this study was to assess the prevalence of thyroid diseases in patients with Diabetes. Therefore, this information can guide physicians to detect and treat this problem better. This cross-sectional study was conducted at the outpatient clinics in King Fahad General Hospital in Jeddah, Saudi Arabia. The prevalence of thyroid disease among all patients with Diabetes was 31.2%. The frequency of patients without or denied any previous thyroid disease was 27.9%. The most frequent thyroid disorder was subclinical hypothyroidism, occurring in 4.2% of patients with type I DM and 35.9% with type II DM. We concluded that screening for thyroid disease among diabetic patients is essential and should be performed routinely due to the high prevalence of new cases diagnosed and the possibility of developing risk factors, such as hypertension and dyslipidemia, arising from undiagnosed thyroid dysfunction. 

References

Barmpari ME, Kokkorou M, Micheli A, Alexiou I, Spanou E, Noutsou M et al. Thyroid dysfunction among Greek patients with type 1 and type 2 diabetes mellitus as a disregarded comorbidity. J Diabetes Res. 2017;2017:6505814. doi: 10.1155/2017/6505814, PMID 29214182.

Afrin G, Misra A, Rathore B, Kumar V, Singh K, Shukla V. Study of prevalence of hypothyroidism in type 2 diabetes mellitus patients of Lucknow and surrounding areas. Era’s J Med Res. 2018;5(2):122-7. doi: 10.24041/ejmr2018.77.

Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782-7. doi: 10.1038/414782a, PMID 11742409.

Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;1;103(2):137-49. doi: 10.1016/j.diabres.2013.11.002, PMID 24630390.

2019. IDF diabetes atlas. (5th edt.). International Diabetes Federation.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 1;27(5):1047-53. doi: 10.2337/diacare.27.5.1047, PMID 15111519.

Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012 Mar 24;379(9821):1142-54. doi: 10.1016/S0140-6736(11)60276-6, PMID 22273398.

Biondi B, Cooper DS. Subclinical hyperthyroidism. N Engl J Med. 2018;378(25):2411-9. doi: 10.1056/NEJMcp1709318, PMID 29924956.

Akbar DH, Ahmed MM, Al-Mughales J. Thyroid dysfunction and thyroid autoimmunity in Saudi type 2 diabetics. Acta Diabetol. 2006;43(1):14-8. doi: 10.1007/s00592-006-0204-8, PMID 16710644.

Shun CB, Donaghue KC, Phelan H, Twigg SM, Craig ME. Thyroid autoimmunity in Type 1 diabetes: systematic review and meta-analysis. Diabet Med. 2014;31(2):126-35. doi: 10.1111/dme.12318, PMID 24103027.

Karunanidhi K, Gunasekaran A. Assessment of thyroid profile in diabetes mellitus at Chengalpattu Medical College and Hospital. Int Arch Integr Med. 2018;5:92-7.

Shahrajabian MH, Sun W, Cheng Q. Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agriculturae Scandinavica Section B — Soil & Plant Science. 2019;69(6):546-56. doi: 10.1080/09064710.2019.1606930.

Wu P. Thyroid disease and diabetes. Clin Diabetes. 1999;18(1):38-9.

Hunter I, Greene SA, MacDonald TM, Morris AD. Prevalence and aetiology of hypothyroidism in the young. Arch Dis Child. 2000 Sep 1;83(3):207-10. doi: 10.1136/adc.83.3.207, PMID 10952634.

De Vries L, Bulvik S, Phillip M. Chronic autoimmune thyroiditis in children and adolescents: at presentation and during long-term follow-up. Arch Dis Child. 2009;94(1):33-7. doi: 10.1136/adc.2007.134841, PMID 18703546.

Jones JH, Mackenzie J, Croft GA, Beaton S, Young D, Donaldson MD. Improvement in screening performance and diagnosis of congenital hypothyroidism in Scotland 1979-2003. Arch Dis Child. 2006;91(8):680-5. doi: 10.1136/adc.2005.088427, PMID 16595645.

Kordonouri O, Hartmann R, Deiss D, Wilms M, Grüters-Kieslich A. Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch Dis Child. 2005;90(4):411-4. doi: 10.1136/adc.2004.056424, PMID 15781936.

Trumpff C, De Schepper J, Vanderfaeillie J, Vercruysse N, Van Oyen H, Moreno-Reyes R et al. Neonatal thyroid-stimulating hormone concentration and psychomotor development at preschool age. Arch Dis Child. 2016;101(12):1100-6. doi: 10.1136/archdischild-2015-310006, PMID 27402733.

Umpierrez GE, Latif KA, Murphy MB, Lambeth HC, Stentz F, Bush A et al. Thyroid dysfunction in patients with type 1 diabetes: a longitudinal study. Diabetes Care. 2003;26(4):1181-5. doi: 10.2337/diacare.26.4.1181, PMID 12663594.

Mayer Jr O, Šimon J, Filipovský J, Plášková M, Pikner R. Hypothyroidism in coronary heart disease and its relation to selected risk factors. Vasc Health Risk Manag. 2006;2(4):499-506. doi: 10.2147/vhrm.2006.2.4.499, PMID 17323605.

S. Aljabri K. Hypothyroidism in Saudi patients with type 1 Diabetes Mellitus. RIJED. 2019;01(1):1-5. doi: 10.37179/rijed.000001.

Ahmed OM, Gabar MA, Ali TM. Impacts of the coexistence of diabetes and hypothyroidism on body weight gain, leptin and various metabolic aspects in albino rats. J Diabetes Complications. 2012 Nov 1;26(6):491-500. doi: 10.1016/j.jdiacomp.2012.05.021, PMID 22770939.

Shahbazian B. H, Mohseni Behbahani A. Assessment of thyroid dysfunction and thyroid auto-antibodies in type 1 diabetes. Jundishapur Sci Med J. 2012;11(1):69-76.

Ashwini S, Bobby Z, Joseph M. Mild hypothyroidism improves glucose tolerance in experimental type 2 diabetes. Chem Biol Interact. 2015;235:47-55. doi: 10.1016/j.cbi.2015.04.007, PMID 25882089.

dos Remedios LV, Weber PM, Feldman R, Schurr DA, Tsoi TG. Detecting unsuspected thyroid dysfunction by the free thyroxine index. Arch Intern Med. 1980;140(8):1045-9. doi: 10.1001/archinte.140.8.1045, PMID 7396608.

Wang W, Teng W, Shan Z, Wang S, Li J, Zhu L et al. The prevalence of thyroid disorders during early pregnancy in China: the benefits of universal screening in the first trimester of pregnancy. Eur J Endocrinol. 2011;164(2):263-8. doi: 10.1530/EJE-10-0660, PMID 21059864.

Bahammam SA, Sharif MM, Jammah AA, BaHammam AS. Prevalence of thyroid disease in patients with obstructive sleep apnea. Respir Med. 2011;105(11):1755-60. doi: 10.1016/j.rmed.2011.07.007, PMID 21820299.

Sunil E, Rajita D, Rajagopal G, Satish P, Suresh V, Laksmi P et al. Sheehan’s syndrome: A single centre experience. Indian J Endocrinol Metab. 2012;1:16.

Dwivedi S, Aggarwal A. Pedigree profile: A valuable tool in the risk assessment of coronary artery disease in young. South East Asian J Prev Cardiol. 2008;12:5-15.

Madrigal JM. Relationships among exposure to environmental pollutants, endogenous hormones, and kidney disease risk ([doctoral dissertation]. University of Illinois at Chicago).

Lin CC, Tsan KW, Chen PJ. The relationship between sleep apnea syndrome and hypothyroidism. Chest. 1992;102(6):1663-7. doi: 10.1378/chest.102.6.1663, PMID 1446468.

Bruyneel M, Veltri F, Poppe K. Prevalence of newly established thyroid disorders in patients with moderate-to-severe obstructive sleep apnea syndrome. Sleep Breath. 2019;23(2):567-73. doi: 10.1007/s11325-018-1746-z, PMID 30368659.

Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29(1):76-131. doi: 10.1210/er.2006-0043, PMID 17991805.

Biondi B, Palmieri EA, Lombardi G, Fazio S. Effects of subclinical thyroid dysfunction on the heart. Ann Intern Med. 2002; 3;137(11):904-14. doi: 10.7326/0003-4819-137-11-200212030-00011, PMID 12458990.

Col NF, Surks MI, Daniels GH. Subclinical thyroid disease: clinical applications. JAMA. 2004;291(2):239-43. doi: 10.1001/jama.291.2.239, PMID 14722151.

Boelaert K, Newby PR, Simmonds MJ, Holder RL, Carr-Smith JD, Heward JM et al. Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med. 2010;123(2):183.e1-9. doi: 10.1016/j.amjmed.2009.06.030. PMID 20103030.

Fallahi P, Ferrari SM, Ruffilli I, Elia G, Biricotti M, Vita R et al. The association of other autoimmune diseases in patients with autoimmune thyroiditis: review of the literature and report of a large series of patients. Autoimmun Rev. 2016;15(12):1125-8. doi: 10.1016/j.autrev.2016.09.009, PMID 27639841.

Published

2022-12-20

How to Cite

Saud Almatani, R. ., Alsahaf, A. S. ., Alluhaybi, M. B. ., Refaai, R. A. ., Alharbi, W. I., & Alhindi, Y. . (2022). Prevalence of Thyroid Diseases in Diabetics Patients at King Fahad General Hospital in Jeddah, Saudi Arabia: Pharmaceutical Science-Pharmacology and therapeutics. International Journal of Life Science and Pharma Research, 13(1), P129-P135. https://doi.org/10.22376/ijlpr.2023.13.1.P129-135

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Section

Research Articles