Impact of Azithromycin and 8-Hydroxychloroquine in 2019 Novel Coronavirus (COVID-19) Pandemic: A Systematic Review

Pharmaceutical Science-Pharmaceutics for effective drug dosage

Abstract

As we know  novel  coronavirus  is an emergent  nuisance  in this stipulated  period.  Corona  virus  is a group  of enveloped  viruses,  with  non-segmented,  single  stranded &  positive  sense  RNA genomes.  Human  Corona virus  is mainly subdivided into four categories such as 229E, NL63, OC43, HKU1. Epidemiologically it has a greater prevalence in the modern era. The features encountered in the clinical course of the disease are multifarious spanning from cough, sneezing, fever, breathlessness.   It   may   take   2-14   days   for   a   person   to   notice   symptoms   after   infection.      Azithromycin   and   8 Hydroxychloroquine  both    plays an instrumental role for management of COVID-19. Azithromycin is a  macrolide antibiotic and it  binds with a 50s ribosome   then inhibits   bacterial   protein synthesis. On the other hand 8-Hydroxychloroquine  was approved by United State in the year of 1955 .Basically it is used as a antimalarial drugs . Briefly, in inflammatory conditions it binds with toll like receptor & blocks them.  8- hydroxychloroquine    increases  lysosomal pH in antigen presenting cells  . In inflammatory conditions it blocks toll like receptors on plasmacytoid dendritic cells. In our review we focused on  the role of Azithromycin, and 8-hydroxychloroquine in Covid-19 .