International Journal of Life science and Pharma Reviews (IJLPR)  
   
  Aim and Scope - To publish peer reviewed review articles in rapidly developing field of Pharma and life sciences  
 
Article
Life Science
Volume 12 Issue 3, May 2022    Pages:73-79
Anti Diabetetic Activity of Illupai Ver Chooranam on Streptozotocin Diabetic Rats

P. Azhagarasi, A. Vijayalakshmi, C. Surya, T. Prabha, N. Kiruthiga, R. Senthil Kumar, P. Selvamani And S. Latha
[View PDF]
DOI: http://dx.doi.org/10.22376/ijpbs/lpr.2022.12.3.L73-79
Abstract:
Roots of Illupai (Madhuca longifolia) are mentioned for Madhumegam in Gunapadam -Mooligai (Siddha Materia Medica). The disease Madhumegam found in siddha text is correlated with Diabetes mellitus type-II. Madhuca longifolia known as Illupai in Tamil has been widely used for the treatment of diabetes. Hence, the present study aimed to demonstrate the antidiabetic effects of Illupai ver chooranam in normal and streptozotocin (STZ) induced diabetic rats. The qualitative phytochemical analysis of the chooranam showed the presence of flavonoids, glycosides, tannins, triterpenoids, polyphenols, carbohydrates, steroids, saponin and proteins. Acute toxicity studies revealed the nontoxic nature of the illupai ver chooranam up to a dose level 2000 mg/kg body weight until the end of the study period. The illupai ver chooranam (500 and 1000 mg/kg) significantly reduced (P**< 0.01) glucose levels in diabetic rats. The other biochemical parameters like cholesterol, lipid, urea, protein, liver glycogen, serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT), were found to be reduced by the illupai ver chooranam. The histopathological results of treated groups showed the regenerative/protective effect on ?-cells of pancreas in diabetic rats. In the oral glucose tolerance test, the illupai ver chooranam increased the glucose tolerance. The current study revealed the antidiabetic potential of illupai ver chooranam effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.
Keywords: Diabetes, Madhumegam, Iluppai ver chooranam, Siddha Medicine, Streptozotocin induced model.
Full HTML:
  1. Imam K. Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus.  Adv. Exp. Med. Biol., 2012; 771: 340–355.  DOI: 10.1007/978-1-4614-5441-0_25
  2. Elosta A, Ghous T and Ahmed N. Natural products as Antiglycation agents: possible therapeutic potential for diabetic complications. Curr. Diabetes Rev., 2012; 8(1): 92– 108.  DOI: 10.2174/157339912799424528
  3. International Diabetes Federation IDF, Diabetes Atlas, 5th edition; 2012.
  4. Spiller HA and Sawyer TS. Toxicology of oral antidiabetic medications. Am J Health Syst Pharm, 2006; 63(10): 929–938.  DOI: 10.2146/ajhp050500
  5. Eurich DT, McAlister FA, Blackburn DF. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure systematic review. Br Med J, 2007; 335(7618): 497–501.  DOI: 10.1136/bmj.39314.620174.80
  6. Saxena A and Vikram NK. Role of selected Indian plants in management of type 2 diabetes: a review. J Altern Complement Med, 2004; 10(2): 369– 378. DOI: 10.1089/107555304323062365
  7. Vipinchandra Bhaskarrao Pande , Saket Singh Chandel and Vishal Son. Synergistic and Safe Antidiabetic Effect of Polyherbal Formulation: Comprehensive Overview. Int. J. Life Sci. Pharma Res. 2021; 11(2): 51-57. doi 10.22376/ijpbs/lpr.
  8. Jung M, Park M, Lee HC, Kan YH, Kang ES, and. Kim SK. Antidiabetic agents from medicinal plants. Curr. Med. Chem. 2006; 13(10): 1203–1218. DOI: 10.2174/092986706776360860
  9. Elder C.2004. Ayurveda for diabetes mellitus: A review of the biomedical literature. Altern Ther Health Med. 2004;10: 44-50. https://pubmed.ncbi.nlm.nih.gov/14727499/
  10. Nadkarni KM. Indian Materia Medica, Vol-I, Popular Prakashan Ltd, Mumbai; 1954. p. 180-181.
  11. Kandasamy Pillai N. History of Siddha Medicine, Govt. of Tamil Nadu, Manorama press, Chennai; 519-520.
  12. Khandelwal KR, Practical Pharmacognosy Techniques and Experiments, Nirali Prakashan, Pune; 2004. p. 149–53.
  13. Organization Economic for Cooperation and Development (OECD). OECD guidelines for the testing of chemicals,Test 425, OECD, France; 2008.
  14. Muraganandan K, Srinivasan S, Gupta PK, Lal J. Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J. Ethno pharm col. 2005; 97: 497-501. DOI: 10.1016/j.jep.2004.12.010
  15. Ilham S, Ali MS, Hasan CM, Kaisar MA, Bachar SC. Antinociceptive and hypoglycemic activity of methanolic extract of Phlogacanthus thyrsiflorus Nees. Asian J. Pharm. Clin. Res. 2012; 5(2): 15-18. https://www.researchgate.net/publication/286514468_Antinociceptive_and_hypoglycemic_activity_of_methanolic_extract_of_Phlogacanthus_thyrsiflorus_Nees
  16. Bonner-Weir S. Morphological evidence of pancreatic polarity of beta cells within islets of langerhans. Diabetes. 1988; 37: 616–621. DOI: 10.2337/diab.37.5.616
  17. WHO. World Health Statistics 2016: Monitoring Health for the SDGs Sustainable Development Goals, World Health Organization; 2016.
  18. Bahare Salehi, Athar Ata,Nanjangud V. Anil Kumar, Farukh Sharopov, Karina Ramírez-Alarcón, Ana Ruiz-Ortega et al. Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules. 2019 Oct; 9(10): 551. doi: 10.3390/biom9100551
  19. Tomlison KC, Gardiner SM, Hebden RA. Functional consequences of streptozotocin induced diabetes mellitus, with particular reference to the cardiovascular system. Pharmacol Rev. 1992;44:103–150. 
  20. Fernandes N, Lagishetty CV, Panda VS, Naik SR. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC Complement Altern Med2007;7:29. doi: 10.1186/1472-6882-7-29
  21. Cantley, James, and Frances M Ashcroft. “Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?.” BMC biology. 2015; 13: 33. doi:10.1186/s12915-015-0140-6.
  22. Mahalingam G, Krishnan K. Antidiabetic and ameliorative potential of Ficus bengalensis bark extract in streptozotocin induced diabetic rats. Indian J Clin Biochem, 2008; 23(4): 394-400. doi: 10.1007/s12291-008-0087-2
  23. Kavalali G, Tuncel H, Goksel S, Hatemi MH. Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats. J. Ethno pharma col. 2002; 84: 241–245. DOI: 10.1016/s0378-8741(02)00315-x
  24. Chattopadhyay R. Hypoglycemic effect of Ocimum sanctum leaf in normal and streptozotocin diabetic rats. Indian J. Exp. Biol.1993; 31: 891–893. PMID: 8112763.
  25. Prato DS and Pulizzi N. The place of sulphonylureas in the therapy for type 2 diabetes mellitus. Metabolism. 2006; 55: 20-27. DOI: 10.1016/j.metabol.2006.02.003
  26. Swanston-Flat SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatment for diabetes: Studies in normal and streptozotocin diabetic mice. Diabetology. 1990; 33: 462–464. DOI: 10.1007/BF00405106
  27. Chatterjea MN, Shinde R. Text Book of Medical Biochemistry, Diabetes mellitus. Jaypee Brothers Medical Publishers, New Delhi; 2002, p. 317.
  28. Whitton PD, Hems DA. Glycogen synthesis in perfused liver of streptozotocin diabetic rats. Biochem. J. 1975; 21: 150–153. DOI: 10.1042/bj1500153

 

 
© 2010-2015 IJLPR rights reserved. Specialized onine journals by ubijournal. Website by Ubitech Solutions