International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 12 Issue 4, July-September 2022    Pages:54-60
Evaluation of Serum IL-17A Levels in Diabetes with Chronic Periodontitis Patients

Sasikumar PK, Sheeja S Varghese , K. Sakthisaranya Devi , Santhosh Sekar and Dhivya S
[View PDF]
DOI: http://dx.doi.org/10.22376/ijpbs/lpr.2022.12.4.P54-60
Abstract:
IL-17A cytokine is a most studied member of the IL-17 cytokine family and its increased production is associated with autoimmune disease and chronic inflammation including periodontitis. This study was aimed to evaluate the serum IL-17A levels in chronic periodontitis patients with or without diabetes. The study was carried out in 168 subjects and consisted of 6 groups wherein group 1 consisted of 28 Type 1 diabetes patients with periodontitis, group 2 consisted of 28 Type 1 diabetes patients without periodontitis, group 3 consists of 28 Type 2 diabetes patients with periodontitis, group 4 consists of 28 Type 2 diabetes patients without periodontitis, group 5 consists of 28 Non-diabetic patients with chronic periodontitis, group 6 consists of 28 Non-diabetic patients without periodontitis (control group). The Sample of 3 ml venous blood was collected from cubital fossa of each subject and analyzed by using ELISA kit. Overall comparison of IL-17A level in between the groups showed that, there was a significant difference (p value < 0.001) among the groups with highest mean level (5.02±0.45) for group-3 (T2DM+CP) followed by group-5 (only CP) and lowest (1.21±0.49) in group-6 (healthy).  The serum IL-17A is significantly high in chronic periodontitis and type 2 diabetes with chronic periodontitis.
Keywords: Serum IL-17A, Chronic Periodontitis, Type 1 Diabetes, Type 2 Diabetes.
 
 
stripe
© 2010-2015 IJLPR. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions