International Journal of Life science and Pharma Reviews (IJLPR)  
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 2 Issue 2, April - June 2012    Pages:22-36
Synthesis, Antibacterial And Anti-Inflammatory Activities Of Some 2-Phenylglyoxylic Acid Derivatives

Craig A. Obafemi,Festus O. Taiwo,Eze
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DOI: DOI not available
Twelve phenylglyoxylic acid derivatives were synthesized, characterized and investigated for their antibacterial activity against nine Gram-positive and four Gram-negative bacterial isolates. Some of the synthesized compounds exhibited broad spectrum activity against the bacterial strains, with 2-[2-(acetylamino)phenyl]-N-(2-chlorophenyl)-2-oxoacetamide (9) being the most active, having MIC values of 7.8-1000 µg/ml and MBC of 31.3-2000 µg/ ml. Seven of the phenylglyoxylic acid derivatives were investigated for their anti-inflammatory activity (acute inflammation, pulmonary oedema and leucocyte counts) in mice. The reduction in oedema formation was between 22-67 % for all the synthesized compounds. The compounds showed significant anti-inflammatory activity with 2-[2-(acetylamino)phenyl]-N-(2,4-dichlorophenyl)-2-oxoacetamide (13) being the most active, while others appear variously dose-dependent.
Keywords: Phenylglyoxylic acid amides, Synthesis, Antibacterial activity, Anti-inflammatory activity.
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