International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 2 Issue 2, April - June 2012    Pages:1-6
Anti-Inflammatory Activity Of Calcium Channel Blockers

Gitanjali Kothiyal,B.Gupta And Vijay Thawani
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DOI: DOI not available
Abstract:
Objective: To explore the anti-inflammatory activity of calcium channel blockers. Material and Methods: The anti-inflammatory activity was determined by producing inflammation in rats of either sex. Acute inflammation was produced by injecting carrageenan, formalin and histamine in hindpaw of rats. For sub-acute inflammation the cotton pellets granuloma method was employed. Formaldehyde induced arthritis was used as a model of chronic inflammation. Result: The acute inflammation produced by carrageenan, histamine and formaldehyde was significantly reduced by pretreatment with Ca++ channel blockers of di-hydropyridine group P< 0.01 exception being Nimodipine which showed varied results. Similarly in sub-acute inflammation model of cotton pellet implantation the drugs showed significant inhibition of inflammation exception being Nimodipine which showed significant protection in high dose 40mg/kg oral P< 0.01.In chronic arthritis induced by formaldehyde there was a dose dependent reduction in paw oedema varying from P< 0.05 at 10mg/kg oral dose to P< 0.01 at 40mg/kg dose. Conclusion: These findings suggest that CCBs exert significant dose dependent anti-inflammatory activity against acute, sub acute and chronic models of inflammations.
Keywords: CCBs (Calcium channel blockers) of 1,4 di-hydropyridine group, anti-inflammatory activity,phlogestic agents, Acute, Sub acute and Chronic models of inflammation.
 
 
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