International Journal of Life science and Pharma Reviews (IJLPR)  
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 10 Issue 5, December 2020    Pages:111-117
Effect of Excipients on Pharmaceutical Parameters on Topical Gel Loaded With Povidone Iodine, Honey and Aloe Vera

Jamal Mohamed A, Perinbam K, Vahitha V, Devanesan S and Janaki Raman KK
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DOI: 10.22376/ijpbs/lpr.2020.10.5.P111-117
The aim of the study is to formulate and evaluate topical gels prepared with povidone iodine, honey and aloe vera using carbopol and poloxamer. Ninetopical gels were formulated using carbopol and poloxamerat various concentrations and evaluated for, rheological properties, in vitro drug release profile, release mechanism and in vitro antimicrobial activity, pH, spreadability, viscosity, flow index and flow behaviour for all the formulations and were found  within acceptable range. The F8 has 99% of cumulative drug release percentage. The invitro mechanism release showed that F8 fits with first order kinetics (r2 = 0.9967) followed by Higuchi model (r2 = 0.9657) diffusion process based on Fick’s Law. F8 formulation showed minimum inhibitory one of 34.46 mm and 27.57 mm for antibacterial and antifungal activity respectively, which exhibited more prominently than other formulations. Based on the findings, it was concluded that F8 has an effective antimicrobial activity and maximum drug release.
Keywords: Povidone Iodine, Honey, Aloe vera, Carbopol 940, Poloxamer, Drug Kinetics
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