International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 10 Issue 5, December 2020    Pages:46-55
Formulation and In Vitro in Vivo Evaluation of Anti-Acne Gel Containing Peanut Skin Extract

Nilima A. Chaudhari, Ashwini P. Katke, Mr.Shoib I.Quureshi, Miss. S.F zeenat Ferheen and Shaikh Siraj N
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DOI: 10.22376/ijpbs/lpr.2020.10.5.P46-55
Abstract:
Acne vulgaris is a common skin disorder affecting more than 85% of the population of the world. Management of acne consists of use of topical or systemic antibiotics, retinoids etc. Prolonged use of antibiotics may lead to the development of antibiotic resistance and various side effects. Due to the increasing frequency of intake of antibiotics, expensive and its side effects, there is a need to focus on the scientific exploration of herbal drugs. Peanut or groundnut taxonomically classified as Arachishypogaeais a species of legume that belongs to the family of Fabaceae, has antibacterial, antioxidants and anti-inflammatory properties. The objective of the study was to develop a topical poly herbal gel for the treatment of mild acne vulgaris. Six different formulations of the herbal gel from ethanolic extract of peanut skin (EEPS) were prepared by varying the proportions of polymers Carbopol934 and Xanthan gum  as a gelling agent and evaluated for their physicochemical properties like pH, spread ability, viscosity and microbial assay, skin irritation and its comparison with marketed product. Peanut skin was extracted using ethanol reflux method. An anti-acne activity of the extract of the peanut skin was performed by Kirby-bauer diffusion method using S. Epidermidis, P.acne. Antibacterial activity against P.acne and S. epidermidis was 7.6 mm and 6.6mm respectively. In comparative study of the formulation compared with marketed products, the zone of inhibition of peanut skin extract and marketed product against P.acne and S. epidermidis was 11.1mm, 10.4mm, 8.3mm and 7.6mm respectively. The visual inspection of the prepared formulation indicated no lumps and had uniform brown color dispersion, free from any fiber and particle, pH was found to be in the range 6.2-6.8, near to the skin pH which indicates that the prepared formulation is compatible with skin and viscosity found to be in the range of 2342±0.8-2704±1.2cps. In vivo Animal studies revealed no pathological lesions. It was observed that the developed peanut skin extract formulation has good minimum inhibitory concentration; it may be due to phytoconstituents present in the peanut skin extract. Finally we concluded that the developed herbal gel containing peanut skin extract which is non-toxic, safe, effective and will improves patient compliance.
Keywords: Acne vulgaris, peanut skin extract, topical gel, S. epidermidis, P. acne.
 
 
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