International Journal of Life science and Pharma Reviews (IJLPR)  
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 10 Issue 5, December 2020    Pages:27-32
Diagnosis and Management of Insulin Resistant Polycystic Ovarian Syndrome: A Simplified Review

Bhavana Kasireddy, SamataSai Patnaik, K.Sridevi and S. Ashok Krishnan
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DOI: 10.22376/ijpbs/lpr.2020.10.5.P27-32
Polycystic Ovarian Syndrome abbreviated as PCOS is one of the common leading endocrine syndromes in middle aged women. PCOS itself is a collection of metabolic risks and symptoms such as hyperandrogenism, infertility, hyperinsulinemia, dyslipidemia, ovulatory dysfunction, type 2 diabetes and endometrial cancer and increased blood pressure Some of these metabolic risks are the physiological drivers of the syndrome and one such risk is insulin resistance. Around 50-70% of the women diagnosed with PCOS are showing the symptoms of insulin resistance. Despite obesity, insulin resistance is seen in both lean and obese PCOS patients. But obesity may be part of the reason for insulin resistance in women with PCOS. Hence hyperandrogenism is more favoured in women with obesity. Although IR associated with PCOS is a common feature, dysregulation of the insulin activity is related to the pathogenesis of PCOS. This chronic condition will escort the syndrome to major metabolic disorders substantially increasing the risk for developing diabetes (prediabetes or type2 diabetes) and furthermore increased hyperandrogenism. Various tests have been developed to determine the insulin resistance like HOMA-IR, clamp techniques, glucose and insulin levels. In addition, till to date diverse advanced markers have been proposed in the scientific literature to diagnose insulin resistance, PCOS and their association. Further research into the basic fundamentals of the syndrome is necessary to manage the disorder. The purpose of this review article is to deliver the simplified view on insulin resistance PCOS for the better understanding of the etiology, symptoms, diagnosis and therapeutic management.
Keywords: Polycystic ovarian syndrome (PCOS), Insulin resistance, Endocrine disorder, Hyperandrogenism, Hormonal imbalance, Biomarkers, Hyperinsulinemia.
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