International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 6 Issue 4, October - December 2016    Pages:22-29
A SIMPLE HPLC METHOD FOR IN-VITRO DISSOLUTION STUDY OF SERTRALINE HYDROCHLORIDE IN TABLETS

SUSHIL P. NARKHEDE, SANTOSH KUMAR SINGH, G.VIDYASAGAR
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DOI: DOI not available
Abstract:
The main aim of present work was to develop and validate a dissolution test for Sertraline Hydrochloride in tablets using HPLC method. The dissolution established conditions were: 900 ml of 0.05M Acetate buffer pH 4.5 as dissolution medium, using a paddle apparatus at a stirring rate of 75 rpm. The chromatographic condition employed a C-18 column (Eurospehere, 250 x 4.6mm, 5┬Ám), isocratic elution with Acetonitrile:Methanol:Phosphate buffer pH 3 (20:50:30 V/V/V) and UV detection at 274 nm. The method was validated to meet requirements for a global regulatory filing. The dissolution test developed was adequate for its purpose and could be employed for routine quality control of Sertraline Hydrochloride tablets.
Keywords: Sertraline Hydrochloride, Dissolution method, HPLC, Validation
 
 
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