International Journal of Life science and Pharma Reviews (IJLPR)  
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 1 Issue 1, October - December 2011    Pages:17-20
Comparative study on the antimicrobial activity of berberis aristata from different regions and berberine in vitro

Pasrija Anubhuti, Singh Rahul And Katiyar Chandra Kant
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DOI: DOI not available
Berberis aristata belongs to genus Berberis of family Berberidaceae. Most of the species belonging to this genus are very popular indigenous drugs found in India [1]. The present work is mainly focused on screening the antimicrobial activity of aqueous and ethanolic extracts of Berberis aristata stems from three different regions viz. Uttaranchal (BR-1), Bihar (BR-2) and Nepal (BR-3) and berberine, an active principle of Berberis aristata, against five bacterial strains including Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis and one fungal strain Aspergillus niger by agar diffusion method by measuring the zone of inhibition by turbidity method and a comparative study was done for the antimicrobial activity of the plants from these regions. HPTLC fingerprinting of Berberis aristata extracts showed that berberine was present in all the three Berberis aristata samples, it was concluded that the observed antimicrobial activity was due to berberine present in the samples used in this investigation.
Keywords: Berberis aristata, antimicrobial activity, alcoholic extract
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