International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 6 Issue 3, July-September 2016    Pages:01-07
IN VITRO ANTIMICROBIAL AND ANTIDIABETIC ACTIVITY OF LEAF EXTRACTS OF SCHREBERA SWIETENIOIDES AND HOMALIUM ZEYLANICUM

V.ANURADHA DEVI* AND K.MALLIKARJUNA1
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DOI: DOI not available
Abstract:
This study was performed to evaluated the antimicrobial and antidiabetic activities of Indian medicinal plants Schrebera swietenioides and Homalium zeylanicum. The leaves of the plants were extracted with ethyl acetate, methanolic and aqueous solvents to give respective extracts. The ethyl acetate, methanolic and aqueous solvent extracts were evaluated for the medicinal activities. Antimicrobial activity of the plant extracts were evaluated by determining the minimum inhibitory concentration values. Different pathogenic organisms including four Bactria (B.subtilis, S. aureus, P.aeruginosa, E.coli) and one fungus (A.niger) were evaluated for antimicrobial activity. Antidiabetic activity was studied by inhibition of α- amylase enzyme using Spectrophotometer. The Methanolic extracts of both plants shows high inhibition activity on E.coli where as water extract inhibits the other pathogenic strains in the study. Both the plants in the study were found to having α- amylase inhibiting activity. H.zeylanicum extract concentration of 200µg/ml was found to be sufficient for 50% inhibition of α- amylase. In S swietenioides, methanolic extract at 250µg/ml and aqueous extract of 200µg/ml concentration of was found to be sufficient for 50% inhibition of α- amylase. This study indicates that the plant leaves contain a variety of compounds contributing to antimicrobial and antidiabetic activity, which could be used for food additives and the development of useful natural compounds.
Keywords: Schrebera swietenioides, Homalium zeylanicum, antidiabetic activity, antimicrobial Activity
 
 
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