International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 5 Issue 3, July - September 2015    Pages:13-16
SYNTHESIS, CHARACTERIZATION AND ANTI MICROBIAL ACTIVITY OF NOVEL CHALCONES AND ITS DI HYDRO PYRIMIDINENONES

CH.M.M.PRASADA RAO*,D.DHACHINAMOORTHI,M.MOUNIKA,M.PAVANI,SK. SHIREENNAAZ,CH. SRAVANI REDDY AND M. SRI ANNAPURNA
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DOI: DOI not available
Abstract:
Novel chalcones were synthesized by condensing 1-(2-chlorophenyl) ethanone with aromatic aldehydes derivatives in dilute ethanolic sodium hydroxide solution at room temperature according to Clasein-Schmidt condensation reaction. The synthesized chalcones compounds were reacted with urea and ethanol upon cyclisation gives pyrimidone derivatives .All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.
Keywords: Chalcones, Pyrimidone, Antimicrobial activity, Clasein-Schmidt condensation
 
 
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