International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Life Science
Volume 5 Issue 2, April - June 2015    Pages:46-53
CAPSAICIN AND GUT MOTILITY

SHUCHITA SINGH AND MALOY B. MANDAL
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DOI: DOI not available
Abstract:
Capsaicin is one of the most important capsaicinoids and forms the main pungent ingredient of chili peppers. It is known to release biologically active substances which affect motility of gut in different species. In human, capsaicin has been shown to alter gastric emptying time and capsaicin receptors have been implicated in irritable bowel syndrome (IBS). Capsaicin, acts through capsaicin receptor, Transient receptor potential subtype 1 (TRPV1). Capsaicin receptor immunoreactivity has been also reported in different parts of the gut in different mammalian species. Studies indicated that capsaicin mediate its effect by releasing endogenous substances like tachykinins, calcitonin gene related peptide (CGRP) and other substances in gut. The present review concentrates on effect of capsaicin on gut motility.
Keywords: Capsaicin, gut, motility, TRPV1.
 
 
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