International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Life Science
Volume 1 Issue 1, October - December 2011    Pages:94-100
Simultaneous Determination Of Chlorpheniramine Maleate, Paracetamol And Pseudoephedrine Hydrochloride In Pharmaceutical Preparations By Hplc

Sandeep Rajurkar
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DOI: DOI not available
Abstract:
A simple, precise and specific reverse-phase High performance liquid chromatography method was developed for identification and simultaneous determination of Chlorpheniramine maleate, Paracetamol and Pseudoephedrine Hydrochloride in capsules and liquids. The separation of three components was performed on C18, 150 x 4.6 mm, 5ยต HPLC column using gradient mobile phase Methanol-Sodium Perchlorate (0.043M, 2 mLTriethylamine, pH 5.0) at a flow rate of 1.0 mL, detection was at 204nm for Chlopheniramine maleate, Pseudoephedrine and 300 nm for Paracetamol.Results have shown good separation of the three component:The recovery of the drugs ranged from 98 to 102%.Validation results showed that the method is selective, linear, accurate and precise.
Keywords: Chlorpheniramine maleate, Paracetamol and Pseudoephedrine Hcl, HPLC, UV detection
 
 
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