International Journal of Life science and Pharma Reviews (IJLPR)  
   
 
International Journal of Life science and Pharma Research (IJLPR)
Pharmaceutical Sciences
Volume 2 Issue 4, October - December 2012    Pages:1-10
MIRTAZAPINE PHARMACOKINETICS IN HEALTHY THAI VOLUNTEERS

SURACHET PONGTANYA,KITTIPONG SANICHWANKUL,SOMKUAN WANMANEE,BUSAKORN SOMBOON AND WANIDA PUMPAISALCHAI
[View PDF]
DOI: DOI not available
Abstract:
Mirtazapine (MZP) is a third-generation antidepressant with a dual mode of action. To investigate the pharmacokinetic profile of MZP in 22 healthy Thai volunteers (12 males, 10 females), each volunteer received a single 30mg oral dose of MZP in the form of conventional tablets, in the fasting state. Serial blood samples were taken and MZP plasma concentrations were measured from 0 to 72 h by a HPLC-UV spectrometry validated method. Pharmacokinetic parameters were calculated and statistically analyzed from MZP plasma levels. Means ± standard deviations of the pharmacokinetic parameters were as follows: The rate of absorption, as measured by peak level (Cmax) and peak time (tmax) were 169.9 ± 31.5 ng ml−1 and 0.6 ± 0.2 h, respectively. The extent of absorption, as measured by area under the curve from zero time to the last measurable sampling time (AUC0-last), and total area under the curve from time zero to infinity (AUC0-inf), were 564.4 ± 241.6 ng ml−1 h and 678.6 ± 283.9 ng ml−1 h, respectively. Elimination rate, characterized by termination half-life (t1/2), was 10.4 ± 5.6 h. A comparison with published pharmacokinetic studies on MZP demonstrated a significantly greater absorption rate and elimination in Thai subjects. Meanwhile, the total extent of absorption (AUC0-inf ) of MZP was not different (p>0.05).
Keywords: pharmacokinetic, antidepressant, NaSSA, HPLC, absorption, elimination, half-life
 
 
stripe
© 2010-2015 IJLPR. All rights reserved. Specialized online journals by ubijournal. Website by Ubitech Solutions